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S-Methylisothiourea sulfate

产品编号 T22419Cas号 867-44-7
别名 (S)-Methylisothiourea sulfate, S-甲基异硫脲硫酸盐, S-甲基异硫脲半硫酸盐

S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。

S-Methylisothiourea sulfate
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S-Methylisothiourea sulfate

纯度: 99.58%
产品编号 T22419 别名 (S)-Methylisothiourea sulfate, S-甲基异硫脲硫酸盐, S-甲基异硫脲半硫酸盐Cas号 867-44-7

S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。

规格价格库存数量
10 mg¥ 256现货
25 mg¥ 413现货
50 mg¥ 588现货
100 mg¥ 882现货
500 mg¥ 2,180现货
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纯度:99.58%
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产品介绍

生物活性
产品描述
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
体外活性
S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
体内活性
S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].
动物实验
S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1].
别名(S)-Methylisothiourea sulfate, S-甲基异硫脲硫酸盐, S-甲基异硫脲半硫酸盐
化学信息
分子量139.18
分子式C2H6N2S·1/2H2O4S
CAS No.867-44-7
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: 60 mg/mL (431.09 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
H2O
1mg5mg10mg50mg
1 mM7.1849 mL35.9247 mL71.8494 mL359.2470 mL
5 mM1.4370 mL7.1849 mL14.3699 mL71.8494 mL
10 mM0.7185 mL3.5925 mL7.1849 mL35.9247 mL
20 mM0.3592 mL1.7962 mL3.5925 mL17.9624 mL
50 mM0.1437 mL0.7185 mL1.4370 mL7.1849 mL
100 mM0.0718 mL0.3592 mL0.7185 mL3.5925 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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